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Fishing single molecules on live cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
32848 44945 2009 7 PDF Available
Title
Fishing single molecules on live cells
Abstract

SummaryA crucial challenge in cell biology is to understand how cell surface-associated molecules are organized, and how they interact with their environment. Clarification of these issues is central to our understanding of the functions of cell surfaces (e.g. cell adhesion), and of their implication in biomedicine (e.g. pathogen interactions). The past years have witnessed rapid progress in our use of atomic force microscopy (AFM) to map the distribution of single polysaccharides and proteins on live cells, and to measure their molecular interactions. These nanoscale analyses complement traditional glycomic and proteomic approaches for the functional analysis of surface-associated molecules, and may help in the search for novel drugs.

Keywords
AFM; Cells; Force spectroscopy; Localization; Manipulation; Microbes; Single molecules
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Fishing single molecules on live cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 4, Issue 3, June 2009, Pages 262–268
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us