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Modeling PHA-producing microbial enrichment cultures—towards a generalized model with predictive power

Paper ID Volume ID Publish Year Pages File Format Full-Text
33319 44969 2014 11 PDF Available
Title
Modeling PHA-producing microbial enrichment cultures—towards a generalized model with predictive power
Abstract

Polyhydroxyalkanoate (PHA) production from waste streams using microbial enrichment cultures is a promising option for cost price reduction of this biopolymer. For proper understanding and successful optimization of the process, a consistent mechanistic model for PHA conversion by microbial enrichment cultures is needed. However, there is still a lack of mechanistic expressions describing the dynamics of the feast–famine process. The scope of this article is to provide an overview of the current models, investigate points of improvement, and contribute concepts for creation of a generalized model with more predictive value for the feast–famine process. Based on experimental data available in literature we have proposed model improvements for (i) modeling mixed substrates uptake, (ii) growth in the feast phase, (iii) switching between feast and famine phase, (iv) PHA degradation and (v) modeling the accumulation phase. Finally, we provide an example of a simple uniform model. Herewith we aim to give an impulse to the establishment of a generalized model.

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Publisher
Database: Elsevier - ScienceDirect
Journal: New Biotechnology - Volume 31, Issue 4, 25 June 2014, Pages 324–334
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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