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Assessment of GE food safety using ‘-omics’ techniques and long-term animal feeding studies

Paper ID Volume ID Publish Year Pages File Format Full-Text
33347 44972 2013 6 PDF Available
Title
Assessment of GE food safety using ‘-omics’ techniques and long-term animal feeding studies
Abstract

Despite the fact that a thorough, lengthy and costly evaluation of genetically engineered (GE) crop plants (including compositional analysis and toxicological tests) is imposed before marketing some European citizens remain sceptical of the safety of GE food and feed. In this context, are additional tests necessary? If so, what can we learn from them? To address these questions, we examined data from 60 recent high-throughput ‘-omics’ comparisons between GE and non-GE crop lines and 17 recent long-term animal feeding studies (longer than the classical 90-day subchronic toxicological tests), as well as 16 multigenerational studies on animals. The ‘-omics’ comparisons revealed that the genetic modification has less impact on plant gene expression and composition than that of conventional plant breeding. Moreover, environmental factors (such as field location, sampling time, or agricultural practices) have a greater impact than transgenesis. None of these ‘-omics’ profiling studies has raised new safety concerns about GE varieties; neither did the long-term and multigenerational studies on animals. Therefore, there is no need to perform such long-term studies in a case-by-case approach, unless reasonable doubt still exists after conducting a 90-day feeding test. In addition, plant compositional analysis and ‘-omics’ profiling do not indicate that toxicological tests should be mandatory. We discuss what complementary fundamental studies should be performed and how to choose the most efficient experimental design to assess risks associated with new GE traits. The possible need to update the current regulatory framework is discussed.

► Transgenesis results in fewer unintended impacts than conventional breeding. ► Environmental factors have been shown to exert a greater impact than transgenesis. ► Some pleiotropic effects do occur when certain pathways are modified. ► No adverse health effects were reported in long-term studies. ► No adverse health effects were reported in multigenerational studies.

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Assessment of GE food safety using ‘-omics’ techniques and long-term animal feeding studies
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Publisher
Database: Elsevier - ScienceDirect
Journal: New Biotechnology - Volume 30, Issue 4, 25 May 2013, Pages 349–354
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us