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Comparative high-throughput RNAi screening methodologies in C. elegans and mammalian cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
33356 44973 2012 12 PDF Available
Title
Comparative high-throughput RNAi screening methodologies in C. elegans and mammalian cells
Abstract

The discovery of RNAi in Caenorhabditis elegans has generated a paradigm shift in how research is performed. Targeted gene knockdown using high throughput screening approaches is becoming a routine feature of the scientific landscape, and researchers can now evaluate the function of each gene in the genome in a relatively short period of time. This review compares and contrasts high throughput screening methodologies in C. elegans and mammalian cells and highlights the breadth of applications of this technology.

► We review recent technological advances in RNAi screening. ► Comparison of C. elegans and mammalian cell culture screens. ► Highlight the pros and cons for selected screening approaches.

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Comparative high-throughput RNAi screening methodologies in C. elegans and mammalian cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: New Biotechnology - Volume 29, Issue 4, 15 May 2012, Pages 459–470
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us