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Induction of hypocrellin production by Triton X-100 under submerged fermentation with Shiraia sp. SUPER-H168

Paper ID Volume ID Publish Year Pages File Format Full-Text
33470 44980 2011 5 PDF Available
Title
Induction of hypocrellin production by Triton X-100 under submerged fermentation with Shiraia sp. SUPER-H168
Abstract

Hypocrellins are important photodynamic therapy compounds for cancer disease. The effect of surfactants on hypocrellin production of Shiraia sp. SUPER-H168 was evaluated under submerged fermentation condition. The production of hypocrellins could reach 780.6 mg/l with the addition of Triton X-100, confirmed by color reaction, high performance liquid chromatography, electrospray ionization mass spectrometry and nuclear magnetic resonance experiments. According to our observation, treatment of the culture at the beginning of the fermentation was most effective, and the yield of hypocrellins was much lower with the addition of Triton X-100 during the log phase and stationary phase. Shiraia sp. SUPER-H168 could not produce hypocrellin with the addition of other tested surfactants, such as Tween 40, Triton X-114 and SDS. The experimental results indicated that Shiraia sp. SUPER-H168 could not produce hypocrellins without Triton X-100 under submerged fermentation condition.

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Induction of hypocrellin production by Triton X-100 under submerged fermentation with Shiraia sp. SUPER-H168
Publisher
Database: Elsevier - ScienceDirect
Journal: New Biotechnology - Volume 28, Issue 6, October 2011, Pages 588–592
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering