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Smart nanocarriers for pH-triggered targeting and release of hydrophobic drugs ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
335 38 2012 9 PDF Available
Title
Smart nanocarriers for pH-triggered targeting and release of hydrophobic drugs ☆
Abstract

The use of hybrid pH-sensitive micelles based mainly on the (PEO)129(P2VP)43(PCL)17 ABC miktoarm star copolymer as potential triggered drug delivery systems was investigated. Co-micellization of this star copolymer with a second copolymer labeled by a targeting ligand, i.e. biotin, on the pH sensitive block (poly-2-vinylpyridine) is considered here in order to impart possible active targeting of the tumor cells. Two architectures were studied for these labeled copolymers, i.e. a miktoarm star or a linear ABC terpolymer, and the respective hybrid micelles are compared in terms of cytotoxicity (cells viability) and cellular uptake (using fluorescent dye loaded micelles). Finally, the triggered drug release in the cytosol of tumor cells was investigated by studying, on the one hand, the lysosomal integrity after internalization and, on the other hand, the release profile in function of the pH.

Keywords
Smart nanocarriers; pH sensitive polymers; Drug delivery; Triggered release
First Page Preview
Smart nanocarriers for pH-triggered targeting and release of hydrophobic drugs ☆
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 12, December 2012, Pages 4215–4223
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering