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Therapeutic applications of antibodies in non-infectious neurodegenerative diseases

Paper ID Volume ID Publish Year Pages File Format Full-Text
33595 44986 2011 7 PDF Available
Title
Therapeutic applications of antibodies in non-infectious neurodegenerative diseases
Abstract

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease, Huntington's disease (HD) or amyotrophic lateral sclerosis (ALS) are all characterised histologically by the presence of deposits of misfolded proteins, tau and amyloid-β, α-synuclein, huntingtin or superoxide dismutase, respectively. Currently, these illnesses do not have any disease modifying treatment options. A novel therapeutic strategy that is being pursued is immunomodulation, which is using the body's immune system to target the self-proteins that are deposited. Most of these promising approaches are still in preclinical development while some have progressed to Phase III clinical trials. As new insights are gained, it is hoped that these immunotherapies will be effective tools at slowing the progression of these debilitating diseases.

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Therapeutic applications of antibodies in non-infectious neurodegenerative diseases
Publisher
Database: Elsevier - ScienceDirect
Journal: New Biotechnology - Volume 28, Issue 5, September 2011, Pages 511–517
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering