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Antiviral activity of ethanol extracts of Ficus binjamina and Lilium candidum in vitro

Paper ID Volume ID Publish Year Pages File Format Full-Text
33815 44990 2009 7 PDF Available
Title
Antiviral activity of ethanol extracts of Ficus binjamina and Lilium candidum in vitro
Abstract

The antiviral activity of plant ethanol extracts against Herpes Simplex Virus-1 and -2 (HSV-1 and HSV-2) and Varicella-Zoster Virus (VZV) was investigated in vitro. Ficus binjamina, resistant to plant viruses, and Lilium candidum, which has a high susceptibility to plant viruses were used. Leaf extracts of F. binjamina inhibited all studied viruses, while its fruit extracts inhibited only VZV. L. candidum leaf extracts had no effect on VZV but strongly inhibited HSV-1 and slightly HSV-2. None of the extracts showed significant cytotoxic effect on uninfected Vero cells even at a concentration of 250 μg/ml (CC50 > 400 μg/ml). The greatest antiviral effect was obtained when extracts were added to cells at the time of infection, whereas a partial inhibitory effect was observed when they were added post-infection. There was indirect evidence for strong interactions between the plant extracts and the viruses and weak interactions with the cell surface.

First Page Preview
Antiviral activity of ethanol extracts of Ficus binjamina and Lilium candidum in vitro
Publisher
Database: Elsevier - ScienceDirect
Journal: New Biotechnology - Volume 26, Issue 6, 31 December 2009, Pages 307–313
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering