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Oxygen transfer in three phase inverse fluidized bed bioreactor during biosurfactant production by Bacillus subtilis

Paper ID Volume ID Publish Year Pages File Format Full-Text
3384 167 2013 7 PDF Available
Title
Oxygen transfer in three phase inverse fluidized bed bioreactor during biosurfactant production by Bacillus subtilis
Abstract

•The effect of main parameters on kLa was studied in fermentation conditions in TPIFB.•The strong influence on kLa of the “in situ” produced biosurfactants was elucidated.•First correlation using dimensional analysis allowing to estimate kLa in TPIFB.•The surface tension variations were considered in the proposed correlation for kLa.

Production of microbial biosurfactants requires development of bioreactors enabling sufficient oxygen supply and foaming control. Gas–liquid mass transfer in a three-phase inverse fluidized bed reactor designed for biosurfactant production by Bacillus subtilis was studied. The influence of main parameters on kLa was investigated in model and real fermentation conditions. Oxygen transfer increased up to 175% and up to 24% with the increase of superficial gas and liquid velocities, respectively. The oxygen transfer obtained in the TPIFB bioreactor (kLa up to 0.015 s−1) was higher than in the other bioreactors used for biosurfactant production. A significant decrease of kLa (up to 27%) was measured during fermentation process. It was shown that this decrease of kLa was a result of surface tension decrease due to the production of biosurfactants. However the oxygen transfer remained important and allowed a correct oxygen supply for the aerobic B. subtilis strains. A correlation based on dimensional analysis was proposed to estimate kLa in function of the influencing parameters, integrating surface tension effects. This correlation allowed estimating correctly kLa in the presence or not of solid particles. The correlation being based on dimensionless numbers, it could help for further process control and scale-up considerations.

Keywords
Fluidized bed bioreactors; Gas–liquid mass transfer; kLa; Biosurfactants; Aerobic processes; Bubble columns
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Oxygen transfer in three phase inverse fluidized bed bioreactor during biosurfactant production by Bacillus subtilis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 76, 15 July 2013, Pages 70–76
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us