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Inhibition of gene expression by RNase P

Paper ID Volume ID Publish Year Pages File Format Full-Text
34095 45002 2010 10 PDF Available
Inhibition of gene expression by RNase P

The ability to interfere with gene expression is of crucial importance to unravel the function of genes and is also a promising therapeutic strategy. Here we discuss methodologies for inhibition of target RNAs based on the cleavage activity of the essential enzyme, Ribonuclease P (RNase P). RNase P-mediated cleavage of target RNAs can be directed by external guide sequences (EGSs) or by the use of the catalytic M1 RNA from E. coli linked to a guide sequence (M1GSs). These are not only basic tools for functional genetic studies in prokaryotic and eukaryotic cells but also promising antibacterial, anticancer and antiviral agents.

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Inhibition of gene expression by RNase P
Database: Elsevier - ScienceDirect
Journal: New Biotechnology - Volume 27, Issue 3, 31 July 2010, Pages 212–221
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Physical Sciences and Engineering Chemical Engineering Bioengineering