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Inhibition of gene expression by RNase P

Paper ID Volume ID Publish Year Pages File Format Full-Text
34095 45002 2010 10 PDF Available
Title
Inhibition of gene expression by RNase P
Abstract

The ability to interfere with gene expression is of crucial importance to unravel the function of genes and is also a promising therapeutic strategy. Here we discuss methodologies for inhibition of target RNAs based on the cleavage activity of the essential enzyme, Ribonuclease P (RNase P). RNase P-mediated cleavage of target RNAs can be directed by external guide sequences (EGSs) or by the use of the catalytic M1 RNA from E. coli linked to a guide sequence (M1GSs). These are not only basic tools for functional genetic studies in prokaryotic and eukaryotic cells but also promising antibacterial, anticancer and antiviral agents.

First Page Preview
Inhibition of gene expression by RNase P
Publisher
Database: Elsevier - ScienceDirect
Journal: New Biotechnology - Volume 27, Issue 3, 31 July 2010, Pages 212–221
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering