fulltext.study @t Gmail

Exploring microRNA functions in zebrafish

Paper ID Volume ID Publish Year Pages File Format Full-Text
34099 45002 2010 6 PDF Available
Title
Exploring microRNA functions in zebrafish
Abstract

The microRNA (miRNA) pathway and the phenomenon of RNA interference (RNAi) have similar mechanisms and depend partly on the same cellular factors. Humans may have more than 1000 different miRNAs, which are essential regulators of gene expression in many biological processes. RNAi-based techniques have become important tools in biomedical research and have great potential for use in disease therapy. Zebrafish (Danio rerio) provide several advantages for the study of miRNA functions. However, reliable RNAi-based gene silencing techniques have not been established for this important vertebrate model. In this article, we describe the highly efficient in vivo assays used to study miRNA functions in zebrafish and how these experimental approaches have uncovered new regulatory mechanisms in vertebrates. This research has also provided information that explains why RNAi techniques have been unsuccessful in zebrafish.

First Page Preview
Exploring microRNA functions in zebrafish
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: New Biotechnology - Volume 27, Issue 3, 31 July 2010, Pages 250–255
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us