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Green synthesis of gold nanoparticles and their enhanced synergistic antitumor activity using HepG2 and MCF7 cells and its antibacterial effects

Paper ID Volume ID Publish Year Pages File Format Full-Text
34164 45007 2016 8 PDF Available
Title
Green synthesis of gold nanoparticles and their enhanced synergistic antitumor activity using HepG2 and MCF7 cells and its antibacterial effects
Abstract

•Green synthesis method to reduce the chemicals and toxicity effects.•Spherical and triangular shaped gold nanoparticles (AuNPs) were synthesized using plants leaf extracts.•Alkaloids, flavonoids and proteins present with AuNPs are responsible for their stabilization, non-agglomeration and biologically active confirmed by FTIR.•AuNPs from mixed extracts show enhanced antibacterial and anticancer activities due to synergistic effect.

One pot green synthesize of gold nanoparticles (AuNPs) were achieved using the leaf extracts of Carica papaya (CP) and Catharanthus roseus (CR) and the combination of these two extracts (CPCRM). The synthesized AuNPs were characterized for their size, morphology, crystallinity and their effects on bacterial and cancer cell lines were investigated. The electron microscopy results showed that AuNPs were mostly spherical, however, triangle and hexagonal shaped morphologies were also observed. The infra-red spectroscopy and microscopies studies revealed that alkaloids, flavonoids and proteins were present along with AuNPs which are responsible for their stabilization, non-agglomeration and biologically active characteristics including antibacterial and anticancer activity. Among the AuNPs prepared in this study, CPCRM extract showed enhanced activity due to the synergistic effects of both plant extracts.

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Keywords
Gold nanoparticle; Green synthesis; Carica papaya; Catharanthus roseus and anticancer activity
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Green synthesis of gold nanoparticles and their enhanced synergistic antitumor activity using HepG2 and MCF7 cells and its antibacterial effects
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 51, Issue 3, March 2016, Pages 384–391
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us