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Development of a structured dynamic model for the production of polyhydroxybutyrate (PHB) in Azohydromonas lata cultures

Paper ID Volume ID Publish Year Pages File Format Full-Text
3423 170 2013 9 PDF Available
Title
Development of a structured dynamic model for the production of polyhydroxybutyrate (PHB) in Azohydromonas lata cultures
Abstract

The development of an accurate model representation of the fermentative production of polyhydroxybutyrate (PHB) is a prerequisite for the optimal operation and control of the microbial process. In the present work, a macroscopic model is developed to quantify the intracellular production of PHB in Azohydromonas lata bacteria. The proposed two-compartment structured model provides an accurate prediction of the metabolic and macroscopic phenomena occurring in A. lata bacterial cultures. Precisely, the proposed dynamic model accounts for biomass growth, polymer accumulation, carbon and nitrogen sources utilization and oxygen mass transfer rates. It is shown that the model can closely describe the time evolution of the bacterial culture via its direct comparison with experiments performed in flasks or/and a bioreactor. Moreover, it is shown that the model can be used as a simulation tool for process optimization and scaling-up studies of the PHB fermentative production in A. lata cultures.

► Dynamic model for the effect of culture conditions on the culture growth. ► Dynamic model for the effect of culture conditions on the PHB production mechanism. ► Transition from biomass-growth dominant phase to PHB-accumulation dominant phase. ► PHB inhibition effect on the biomass growth. ► Model-based scaling-up study of the PHB fermentative production in Azohydromonas lata cultures.

Keywords
Biopolymers; Fermentation; Mathematical modelling; PHB; Structured macroscopic model; Scaling-up of bioprocesses
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Development of a structured dynamic model for the production of polyhydroxybutyrate (PHB) in Azohydromonas lata cultures
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 71, 15 February 2013, Pages 72–80
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us