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Effect of liposome membranes on disaggregation of amyloid β fibrils by dopamine

Paper ID Volume ID Publish Year Pages File Format Full-Text
3429 170 2013 9 PDF Available
Title
Effect of liposome membranes on disaggregation of amyloid β fibrils by dopamine
Abstract

The inhibition of fibril formation of amyloid β (Aβ) and the disaggregation of Aβ fibrils are the promising approaches for a medical treatment of Alzheimer's disease (AD) therapy. In this study, we investigated the effects of liposomes on dopamine-induced disaggregation of Aβ fibrils by using the variety of liposomes. The used liposomes were normal liposomes, raft-forming liposomes, charged liposomes and oxidized liposomes. Those liposome could accelerate the disaggregation rate of fibrils. From the comparison of normal and charged liposomes, a certain contribution of dopamine via an electrostatic interaction to the disaggregation was confirmed. From raft-forming and oxidized liposomes, we revealed a significant contribution of bound water to liposomes, which could assist the formation of the quinine-form of dopamine by a removal of its proton. It is, therefore, concluded that the membrane surface of liposomes is considered to be an adequate environment for the dopamine-induced disaggregation of fibrils.

► The addition of liposome could accelerate the fibril disaggregation by catecholamine. ► Oxidized and negatively charged liposome showed the definite accelerated effect. ► Fibril disaggregation has relation with the bound water to liposome membranes.

Keywords
Alzheimer's disease; Amyloid beta fibrils; Catecholamines; Liposome; Disaggregation
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Effect of liposome membranes on disaggregation of amyloid β fibrils by dopamine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 71, 15 February 2013, Pages 118–126
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us