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Effects of pH probe lag on bioreactor mixing time estimation

Paper ID Volume ID Publish Year Pages File Format Full-Text
34367 45020 2014 4 PDF Available
Title
Effects of pH probe lag on bioreactor mixing time estimation
Abstract

•pH probe response time was investigated to correct empirical mixing time measurement.•The corrected mixing time validated bioreactor CFD models.•The impact of pH probe response time on mixing time measurement was also significant in larger scales.

Mixing time is one of the most important characteristics of bioreactors used to validate computational fluid dynamics (CFD) models in bioprocess. The pH tracer based method is commonly used to estimate mixing time by monitoring the pH change after perturbation to the system. However, pH probe lag is known to introduce errors in the test results. To determine the impact of probe lag on the measurement, pH probe response times were investigated. A second order mathematical model was established to describe the probe response profile and calculate the probe transfer function which was used to correct the empirical results. The corrected mixing time was used to validate the CFD models and also showed that the impact of pH probe response time on mixing time measurement is significant even in larger (pilot and manufacturing) scales. In addition, comparison with a conductance based tracer method is also discussed in this paper.

Keywords
Mixing time; Response time; pH probe; Bioreactor; CFD model
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 49, Issue 6, June 2014, Pages 913–916
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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