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Effect of alcohol-free red wine concentrates on cholesterol homeostasis: An in vitro and in vivo study

Paper ID Volume ID Publish Year Pages File Format Full-Text
34428 45025 1971 8 PDF Available
Title
Effect of alcohol-free red wine concentrates on cholesterol homeostasis: An in vitro and in vivo study
Abstract

•AFRWC was more effective than lovastatin for decreasing total cholesterol in vitro.•Both total cholesterol and LDL-cholesterol are decreased in vivo model using ICR-mice.•Cholesterol biosynthesis and esterification were affected by AFRWC at a transcriptional level.•Reverse cholesterol transport was not affected by AFRWC at a transcriptional level.•2–3 glasses of wine per day for a 60 kg human could influence cholesterol metabolism.

Polyphenolic composition of alcohol-free red wine concentrates (AFRWC) was determined by LC–MS/MS. The concentration of salicylic acid in non-flavonoid class and malvidin in flavonoid class was the highest among all the polyphenols determined in AFRWC. In the in vitro model using HepG2 cells, AFRWC was found to be more effective for the reduction of total cholesterol than lovastatin. For the in vivo model, animals were provided with AFRWC at ∼750 mg of total polyphenols/kg body weight per day by oral administration. The amount of AFRWC was established by extrapolation to be equivalent to 375 ml/day wine consumption, which is ∼2–3 glasses of wine per day for a 60 kg human. Despite a high cholesterol diet, a significant reduction in both total cholesterol and LDL-cholesterol was observed when supplemented with AFRWC, but the increase of HDL-cholesterol was not observed. The expression level of mRNA of some hepatic genes participating in cholesterol biosynthesis, cholesterol esterification was found to be influenced by AFRWC supplementation, whereas reverse cholesterol transport involved with HDL-cholesterol was seldom affected showing discrepancy in the expression of associated genes.

Keywords
Alcohol-free red wine concentrates; Cholesterol homeostasis; Polyphenol; Total cholesterol
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Effect of alcohol-free red wine concentrates on cholesterol homeostasis: An in vitro and in vivo study
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 48, Issue 12, December 2013, Pages 1964–1971
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us