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A cyclohexadepsipeptide from entomogenous fungi Metarhizium anisopliae inhibits the Helicobacter pylori induced pathogenesis through attenuation of vacuolating cytotoxin-A activity

Paper ID Volume ID Publish Year Pages File Format Full-Text
34482 45027 2015 6 PDF Available
Title
A cyclohexadepsipeptide from entomogenous fungi Metarhizium anisopliae inhibits the Helicobacter pylori induced pathogenesis through attenuation of vacuolating cytotoxin-A activity
Abstract

•Destruxin B (Dtx-B) showed inhibitory effects against H. pylori.•Dtx-B inhibited VacA-induced vacuolization in AGS cells.•Dtx-B inhibited V-ATPase activity rather than VacA expression.

Infection with Helicobacter pylori in the gastric mucosa is thought to be increased the risk of peptic ulcer disease and gastric cancer. Vacuolating cytotoxin A (VacA) was an important bacterial virulence factor and was closely associated with H. pylori-induced pathogenesis. Upon H. pylori infection, the VacA can be transferred directly from bacteria into the host cells where can stimulate vacuolar-type ATPase (V-ATPase) proton pump and induce the formation of vacuoles in gastric epithelial cells followed by intoxication of cells. Destruxin B (Dtx-B), a cyclodepsipeptide from the fungus Metarhizium anisopliae bearing insecticidal and anticancer effects. In this study, Dtx-B demonstrated inhibitory effects against H. pylori VacA-induced vacuolization in gastric epithelial cells. Our data further showed that attenuation of H. pylori-induced vacuolization in gastric epithelial cells by Dtx-B is mediated through inhibition of V-ATPase activity rather than VacA expression levels. The results from this study reveal a novel role for Dtx-B in the modulation of H. pylori VacA-induced pathogenesis.

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Keywords
Destruxin B; Helicobacter pylori; Vacuolating cytotoxin A; V-ATPase
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A cyclohexadepsipeptide from entomogenous fungi Metarhizium anisopliae inhibits the Helicobacter pylori induced pathogenesis through attenuation of vacuolating cytotoxin-A activity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 50, Issue 1, January 2015, Pages 134–139
Authors
, , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us