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CFD analysis of the turbulent flow in baffled shake flasks

Paper ID Volume ID Publish Year Pages File Format Full-Text
3453 171 2013 11 PDF Available
Title
CFD analysis of the turbulent flow in baffled shake flasks
Abstract

In this work, computational fluid dynamics (CFD) technique is used to simulate the complicated unsteady-state turbulent flow field formed in baffled flask. The baffled flask shows advantages both in mass transfer capacity and in shear formation in comparison with unbaffled flasks. Detailed investigations of power consumption, mass transfer and shear rate are carried out in baffled flasks under shaking frequencies ranging from 100 rpm to 250 rpm, and filling volumes from 50 mL to 150 mL. The results show that the specific power input and specific interface area are both greatly influenced by shaking frequency and filling volume. For the positive effect of shaking frequency on both mass transfer coefficient (kL) and specific interface area (a), the volumetric mass transfer coefficient (kLa) increases greatly with shaking frequency. Results also show that filling volume has no significant effect on kL but negative effect on specific interface area. Shear force formed in baffled flask shows great dependent on shaking frequency, but it is insensitive to the filling volume. Based on these investigations, correlations linking these parameters are proposed. Finally, cultivations of filamentous fungus conducted in unbaffled and baffled flasks validated the simulating results.

► CFD method was used to simulate the flow field in baffled flaks for the first time. ► Mass transfer and shear environment in baffled flasks were studied comprehensively. ► A new model was used to describe the flask movement. ► Cultivation of filamentous fungus was conducted to validate the simulating results.

Keywords
Shake flask; Hydrodynamics; Mass transfer; Mixing; Shear force; Power consumption
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CFD analysis of the turbulent flow in baffled shake flasks
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 70, 15 January 2013, Pages 140–150
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us