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Antioxidative and ACE inhibitory activities of protein hydrolysates from zebra blenny (Salaria basilisca) in alloxan-induced diabetic rats

Paper ID Volume ID Publish Year Pages File Format Full-Text
34534 45032 2014 8 PDF Available
Title
Antioxidative and ACE inhibitory activities of protein hydrolysates from zebra blenny (Salaria basilisca) in alloxan-induced diabetic rats
Abstract

•ZBPHs show strong antioxydant activity in diabetic rats.•ZBPHs show strong anti-ACE activity under in vitro conditions.•ZBPHs show strong anti-ACE activity in diabetic rats.•ZBPHs improve kidney function in diabetic rats.

The present study investigated the antioxidant properties and angiotensin-I converting enzyme (ACE) inhibitory activities of zebra blenny protein hydrolysates (ZBPHs), obtained by treatment with three different crude enzyme extracts, in alloxan induced diabetic rats (AIDR). The thiobarbituric acid-reactive substances (TBARS) level, as an indicator of lipid peroxidation, and the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were examined. The hepatic antioxidant enzyme activities were significantly decreased and the malondialdehyde (MDA) level was increased in AIDR. Interestingly, the administration of ZBPHs to diabetic rats reduced the MDA concentration and increased the antioxidant enzyme activities. Further, ZBPHs were found to modulate ACE activity. In addition, ZBPHs were observed to protect the kidney function efficiently, which were evidenced by the significant decrease in the creatinine, uric acid and urea contents. These results suggest a strong antioxidant and antihypertensive effect of ZBPHs which can delay the occurrence of diabetic complications and be considered as functional food ingredients in nutraceuticals or pharmaceuticals.

Keywords
Zebra blenny (S. basilisca); Protein hydrolysate; Digestive proteases; AIDR; Antioxidant activity; ACE inhibition activity.
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Antioxidative and ACE inhibitory activities of protein hydrolysates from zebra blenny (Salaria basilisca) in alloxan-induced diabetic rats
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 49, Issue 5, May 2014, Pages 890–897
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us