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Removal of residual methylene chloride from homoharringtonine by pre-treatment with ethanol

Paper ID Volume ID Publish Year Pages File Format Full-Text
34616 45035 2013 5 PDF Available
Title
Removal of residual methylene chloride from homoharringtonine by pre-treatment with ethanol
Abstract

•Residual methylene chloride in HHT was removed through pre-treatment with ethanol.•Residual methylene chloride was effectively removed.•Residual methylene chloride easily met the ICH-specified value.

In this study, methylene chloride, which is a residual solvent in final purified homoharringtonine, was removed effectively through pre-treatment with ethanol. When the final HPLC-purified sample was concentrated using a rotary evaporator, the residual methanol easily met the ICH-specified value (3000 ppm), but methylene chloride did not meet the ICH-specified value (600 ppm). However, when the sample (methylene chloride: 10,000 ppm, methanol: 500 ppm) was concentrated through pre-treatment with 95% ethanol using a rotary evaporator, the residual methylene chloride easily met the ICH-specified value. Also, the residual ethanol (concentration > 10,000 ppm) was removed effectively below the ICH-specified value (5000 ppm) through microwave-assisted drying (microwave power: 400 W).

Keywords
Homoharringtonine; Residual methylene chloride; Removal; Pre-treatment; Ethanol
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Removal of residual methylene chloride from homoharringtonine by pre-treatment with ethanol
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 48, Issue 11, November 2013, Pages 1809–1813
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us