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Biotechnological production of feed nucleotides by microbial strain improvement

Paper ID Volume ID Publish Year Pages File Format Full-Text
34618 45037 2013 8 PDF Available
Title
Biotechnological production of feed nucleotides by microbial strain improvement
Abstract

•Nucleotides are economically important in food and feed industries.•The world feed nucleotides market was estimated to be 22,000 tm in 2010.•Feed nucleotide industries have duplicated its production in the last 3–4 years.•No updated reviews describe the advances on the microbial production nucleotides.

Sodium salts of inosine monophosphate (IMP) and guanosine monophosphate (GMP) are potent flavour enhancers. They are widely used as food additives in combination with monosodium glutamate (MSG) to synergistically increase umami flavour. In recent years, both inosine and guanosine derivatives have gained further importance because of their beneficial effects, related to their antioxidant, neuroprotective, cardiotonic and immunomodulatory properties. The industrial production of both IMP and GMP is mainly achieved either by RNA breakdown and nucleotide extraction or by microbial fermentation using different microorganisms such as Corynebacterium, Bacillus, or Escherichia coli. This work reviews the metabolic pathways and regulatory networks of purine synthesis, including both IMP and GMP, and the biotechnological processes applied to the production of these compounds, ranging from classical random mutagenesis to rational design by metabolic engineering. Recent advances of systems biology approaches, along with the rapid development of synthetic biology, may offer a basis for future manipulations to further increase the productivity of the fermentation processes.

Keywords
AMP, adenosine monophosphate; CMP, cytidine monophosphate; GMP, guanosine monophosphate; GDP, guanosine diphosptate; GTP, guanosine triphosphate; ppGpp, guanosine tetraphosphate; cGMP, cyclic GMP; IMP, inosine monophosphate; UMP, uridine monophosphate; XM
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 48, Issue 9, September 2013, Pages 1263–1270
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us