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Immunomodulatory effects of polysaccharides isolated from Hericium erinaceus on dendritic cells ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
34636 45037 2013 7 PDF Available
Title
Immunomodulatory effects of polysaccharides isolated from Hericium erinaceus on dendritic cells ☆
Abstract

•The bioactive components of HE-PS are determined.•Sugar compositions of HE-PS were glucose, galactose, mannose, and rhamnose.•HE-PS stimulates the maturation of rat dendritic cells (DCs) significantly.•HE-PS induces DC cells activation and modulates the TH1 immune response.

Hericium erinaceus (H. erinaceus; HE) polysaccharides (HE-PS) have been shown to have immunomodulatory activity. We found that the bioactive components of β-glucan derivatives consisted of 20% in HE-PS. We used an analytic platform for investigating the effects of HE-PS on the maturation of rat dendritic cells (DCs), which are derived from rat bone marrow hematopoietic cells (BMHCs). The results showed that treatment with 50 μg/mL HE-PS changed the morphology of the DCs to an active form in parallel with a significant two fold increase in MHC class II and CD80/86 surface antigens compared to the control. Furthermore, endocytosis by the DCs was significantly reduced at the same dosage. IL-12, IFN-γ and IL-10 cytokine secretion was significantly increased by 2.7, 1.5 and 1.6-fold, respectively, compared to the control after treatment with 50 μg/mL of HE-PS. This study used a powered analysis platform to show that HE-PS induces DCs activation and modulates the TH1 immune response. Thus, HE-PS has potential as an immunopotentiating agent that could be further developed in the health food industry.

Keywords
HE-PS, Hericium erinaceus-polysaccharides; DCs, dendritic cells; BMHCs, bone marrow hematopoietic cells; APCs, antigen presenting cells; TCA, trichloroacetic acid; LPS, lipopolysaccharideHericium erinaceus; Bioactive polysaccharides; β-Glucan; Dendritic c
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 48, Issue 9, September 2013, Pages 1402–1408
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Any Questions? feel free to contact us