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Production and characterization of novel chitosan nanoparticles for controlled release of rHu-Erythropoietin

Paper ID Volume ID Publish Year Pages File Format Full-Text
3473 172 2012 9 PDF Available
Title
Production and characterization of novel chitosan nanoparticles for controlled release of rHu-Erythropoietin
Abstract

In this work we report the production and characterization of nanoparticles using the ionotropic gelation method between the biopolymer chitosan (CS) and tripolyphosphate (TPP) ion with simultaneous encapsulation of the glycoprotein Recombinant human erythropoietin (rHu-EPO). Chitosan concentration, chitosan to TPP mass ratio, and solution pH were optimized using response surface modeling to produce nanoparticles containing rHu-EPO. Nanoparticles were produced with diameters ranging from 100 nm to 400 nm, particle polydispersity from 0.2 to 0.4 and nanoparticle surface charge (zeta potential) ranging between 30 and 50 mV. Controlled release of rHu-EPO from CS-TPP nanoparticles was studied and showed 30% release of the original encapsulated rHu-EPO in 24 h and 68% release in two weeks. These rHu-EPO release results can be used as a basis for more research on the application of nanoparticles within animal models.

► Production and characterization of chitosan–TPP nanoparticles. ► Optimization of chitosan nanoparticle characteristics by response surface modeling. ► Controlled release of rHu-Erythropoietin from chitosan nanoparticles.

Keywords
Chitosan; Controlled release; Encapsulation; Erythropoietin; Ionotropic gelation; Nanoparticles; Response surface modeling
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Production and characterization of novel chitosan nanoparticles for controlled release of rHu-Erythropoietin
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 68, 15 October 2012, Pages 61–69
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us