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Formulation and evaluation of water-in-oil amoxicillin-loaded nanoemulsions using for Helicobacter pylori eradication

Paper ID Volume ID Publish Year Pages File Format Full-Text
34808 45049 2012 10 PDF Available
Title
Formulation and evaluation of water-in-oil amoxicillin-loaded nanoemulsions using for Helicobacter pylori eradication
Abstract

Antibiotics have a short residence time and have low concentrations when absorbed through the basolateral membrane in the stomach; this causes a failure to enhance drug concentrations at Helicobacter pylori infection sites. This study developed a nanocarrier system with the ability to carry amoxicillin to increase its efficacy against H. pylori. We used a water-in-oil emulsification system to prepare a positively charged nanoemulsion particle composed of amoxicillin, chitosan, and heparin. The particle size of the prepared nanoemulsion particle was controlled by the constituted compositions. The morphology of the nanoemulsion particles was spherical. In vitro analysis of amoxicillin released indicated that the nanocarrier system controlled amoxicillin release in the gastrointestinal dissolution medium and amoxicillin-loaded nanoemulsion particles localized to the site of H. pylori infection. Meanwhile, results of in vivo clearance assays indicated that the prepared amoxicillin-loaded nanoemulsion particles had a significantly greater H. pylori clearance effect in the gastric infection mouse model than the amoxicillin solution alone.

► Helicobacter pylori have been considered to peptic ulcer etiological factor. ► Helicobacter pylori could colonize deeply within the gastric mucus layer. ► Antibiotic has low concentrations are absorbed at H. pylori infection sites. ► The nanoemulsion particles carried amoxicillin to the H. pylori infection site. ► The amoxicillin-loaded particles also had significant H. pylori clearance effect.

Keywords
Helicobacter pylori; Amoxicillin; Emulsification system; Nanoemulsion particle
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Formulation and evaluation of water-in-oil amoxicillin-loaded nanoemulsions using for Helicobacter pylori eradication
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 47, Issue 10, October 2012, Pages 1469–1478
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us