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Statistical optimization of high temperature/pressure and ultra-wave assisted lysis of Urechis unicinctus for the isolation of active peptide which enhance the erectile function in vitro

Paper ID Volume ID Publish Year Pages File Format Full-Text
34836 45051 2014 6 PDF Available
Title
Statistical optimization of high temperature/pressure and ultra-wave assisted lysis of Urechis unicinctus for the isolation of active peptide which enhance the erectile function in vitro
Abstract

•The optimal hydrolysis condition to obtain a peptide from Urechis unicinctus was optimized.•High temperature/pressure and ultra-wave were applied as physical hydrolysis methods.•Lysed peptide, DDL showed the potential to enhance erectile function in vitro.•The lysis process of U. unicinctus was strongly affected by the temperature factor.

High temperature/pressure and ultra-waves could be applied to lyse substances into small units to facilitate absorbance in the human intestine. Hydrolysed substances are widely reported for their specific bioactivities. However, the establishment of optimal condition for the lysis process is crucial for their prospective commercial applications. Consumption of marine echiuran worm, Urechis unicinctus (U. unicinctus) is generally known to enhance erectile function. However, there are less scientific reports on the same. In this study efforts were taken to optimize the high temperature/pressure and ultra-wave assisted lysis conditions to isolate active peptide with erectile function inducing activity. According to the results the isolated peptide (DDL, 361.15 Da) showed a high potential to enhance erectile function in vitro. The optimal lysis conditions for the isolation were analyzed using response surface methodology (RSM).

Keywords
Response surface methodology (RSM); Urechis unicinctus (U. unicinctus); High temperature/pressure; Ultra-wave, Erectile function
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Statistical optimization of high temperature/pressure and ultra-wave assisted lysis of Urechis unicinctus for the isolation of active peptide which enhance the erectile function in vitro
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 49, Issue 1, January 2014, Pages 148–153
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us