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Bioperformance interpretation of a two-stage membrane bioreactor with cell recycling for intensive microbial production using residence time and internal age distributions ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
34842 45052 2013 12 PDF Available
Title
Bioperformance interpretation of a two-stage membrane bioreactor with cell recycling for intensive microbial production using residence time and internal age distributions ☆
Abstract

Residence time distribution (RTD) and internal age distribution (IAD) approaches were used to investigate complex interactions between hydrodynamics and biological activity in an innovative two-stage continuous membrane bioreactor with cell recycling. This bioprocess was designed to investigate the behaviour of yeast (Saccharomyces cerevisiae) in extreme conditions and to intensify bioproduction. Based on established RTD/IAD models, a parametric study was conducted considering biological constraints (growth rate, viability and products kinetics) under realistic working conditions (reactor volume, feed, bleed, permeate and recirculation flowrates). Competition between internal recirculation and dilution rates was observed and described by a dimensionless circulation index, K. Bioprocess performance (cell viability, substrate and ethanol concentrations) was discussed according to RTD/IAD simulations of 12 cultures. Assuming a critical residence time within the second stage enabled us to define acceptable and unacceptable working conditions to maintain biological activity.

Keywords
Membrane bioreactor; High cell density; Residence time distribution; Internal age distribution; Parametric study; Biological performance; Viability; Yeast
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Bioperformance interpretation of a two-stage membrane bioreactor with cell recycling for intensive microbial production using residence time and internal age distributions ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 48, Issue 1, January 2013, Pages 13–24
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us