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Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture

Paper ID Volume ID Publish Year Pages File Format Full-Text
34863 45052 2013 6 PDF Available
Title
Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture
Abstract

The flavonolignan isosilybin (1) is one of the silybin congeners contained in the silymarin complex, which is isolated from the seeds of the milk thistle (Silybum marianum). A number of recent studies have demonstrated that isosilybin is probably the most potent anticancer agent found in silymarin. It occurs as a mixture of two diastereoisomers, A and B. Lipase Novozym 435 was found to allow the preparative production of both optically pure isosilybin A and B in a diastereoisomeric purity of over 95%. A preparatory method based on the enzymatic resolution and other purification methods has been developed, enabling multigram amounts of both optically pure isosilybins A (1a) and B (1b) to be obtained.

► Isosilybin is probably the most potent anticancer compound in silymarin. ► Preparatory method for isolation of optically pure isosilybin A and B was developed. ► A core of the method is diastereomeric discrimination with lipase Novozym 435. ► Other pure silymarin components, such as taxifolin and silydianin can be obtained.

Keywords
Isosilybin; Silymarin; Novozym 435; Silybin; Diastereomers
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Preparative method for isosilybin isolation based on enzymatic kinetic resolution of silymarin mixture
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 48, Issue 1, January 2013, Pages 184–189
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us