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Photobioreactor scale-up for a shear-sensitive dinoflagellate microalga

Paper ID Volume ID Publish Year Pages File Format Full-Text
34881 45056 2011 9 PDF Available
Title
Photobioreactor scale-up for a shear-sensitive dinoflagellate microalga
Abstract

Large scale culture of marine dinoflagellate microalgae has proved difficult owing to their extreme sensitivity to hydrodynamic forces in photobioreactors. This work discusses the scale up of Protoceratium reticulatum dinoflagellate culture from a successful 2 L stirred-tank photobioreactor operation to a 15 L stirred photobioreactor. Both bioreactors were equipped with internal spinfilters for cell retention. A semicontinuous perfusion culture in the 15 L photobioreactor proved to be more productive than fed-batch perfusion culture. Under the best operational conditions, the average cell productivity in the 15 L photobioreactor was 5228 cell mL−1 day−1, or nearly 3.7-fold greater than the best attainable value in static flask cultures, but similar to the results obtained in the 2 L stirred tank. At 9.16 μg L−1 day−1 the average volumetric productivity of yessotoxin in the scaled up operation in the semicontinuous perfusion mode was comparable to the results obtained in the small bioreactor. P. reticulatum has a cell damage threshold shear rate of as low as 0.1 s−1. Notwithstanding this extreme shear sensitivity, the results suggest a good potential for mass scale culture of this dinoflagellate in suitably designed photobioreactors.

Keywords
Dinoflagellates; Protoceratium reticulatum; Microalgae; Photobioreactors; Yessotoxins; Shear rate
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Photobioreactor scale-up for a shear-sensitive dinoflagellate microalga
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 46, Issue 4, April 2011, Pages 936–944
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us