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Solid-state fermentation: Physiology of solid medium, its molecular basis and applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
34918 45060 2012 11 PDF Available
Title
Solid-state fermentation: Physiology of solid medium, its molecular basis and applications
Abstract

Solid-state fermentation is an alternative culture method that has gained researchers attention over the past 20 years. There are several advantages in employing many SSF processes over the conventional submerged fermentation (SmF) ones, like higher yields of secondary metabolites or enzymes. Moreover, certain enzymes and secondary metabolites can only be produced in SSF. Many of these advantages are related to the special physiology shown by fungi in SSF. This review refers to this physiology (i.e. a behavior that deviates from the one displayed by the fungus in liquid medium), sometimes referred to as “physiology of solid medium”, and its molecular basis. The reason for this different physiology in SSF is not fully understood, but recent advances are beginning to draw an interesting and wide panorama. Higher secondary metabolites production has been related to higher transcription of the biosynthetic genes; while studies on enzymes production in SSF have identified SSF-specific genes and provided deeper insight into their genetic expression and regulation. Moreover, some solid culture environmental stimuli (signals) have been identified. Many of these basic findings are also starting to be applied to new genetic improvement methods, novel culture systems, and other technological advances.

► Advantages of solid-state fermentation (SSF) relate to special physiology of fungi in solid medium. ► Higher secondary metabolites production in SSF is due to higher transcription of biosynthetic genes. ► SSF-specific enzyme genes provided deeper insight into their genetic expression and regulation. ► Some SSF-specific environmental cues: low Aw, high temperature and barriers to hyphal extension. ► Some basic findings are being applied to new genetic improvement methods, novel culture systems, etc.

Keywords
Physiology of solid medium; Gene expression differences; Regulation
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Solid-state fermentation: Physiology of solid medium, its molecular basis and applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 47, Issue 2, February 2012, Pages 175–185
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us