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Rhamnolipids as biosurfactants from renewable resources: Concepts for next-generation rhamnolipid production

Paper ID Volume ID Publish Year Pages File Format Full-Text
35076 45073 2012 13 PDF Available
Title
Rhamnolipids as biosurfactants from renewable resources: Concepts for next-generation rhamnolipid production
Abstract

Several microorganisms are known to produce a wide variety of surface-active substances, which are referred to as biosurfactants. Interesting examples for biosurfactants are rhamnolipids, glycolipids mainly known from Pseudomonas aeruginosa produced during cultivation on different substrates like vegetable oils, sugars, glycerol or hydrocarbons. However, besides costs for downstream processing of rhamnolipids, relatively high raw-material prices and low productivities currently inhibit potential economical production of rhamnolipids on an industrial scale. This review focuses on cost-effective and sustainable production of rhamnolipids by introducing new possibilities and strategies regarding renewable substrates. Additionally, past and recent production strategies using alternative substrates such as agro-industrial byproducts or wastes are summarized. Requirements and concepts for next-generation rhamnolipid producing strains are discussed and potential targets for strain-engineering are presented. The discussion of potential new strategies is supported by an analysis of the metabolism of different Pseudomonas species. According to calculations of theoretical substrate-to-product conversion yields and current world-market price analysis, different renewable substrates are compared and discussed from an economical point of view. A next-generation rhamnolipid producing strain, as proposed within this review, may be engineered towards reduced formation of byproducts, increased metabolic spectrum, broadened substrate spectrum and controlled regulation for the induction of rhamnolipid synthesis.

► Current needs and future trends for rhamnolipid production are highlighted. ► We discuss strategies and obstacles towards next-generation rhamnolipid production. ► We present concepts and targets for potential optimization of rhamnolipid production by strain-engineering. ► We support these approaches by an in-depth view on Pseudomonas sp. metabolic network. ► We summarize the current market situation of different renewable feedstocks and potential yields.

Keywords
Rhamnolipid; Biosurfactant; Pseudomonas aeruginosa; Metabolic engineering; Renewable resource; Renewable feedstock
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 47, Issue 8, August 2012, Pages 1207–1219
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us