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Exploring the potential of biopharmaceutical production by Rigidoporus ulmarius: Cultivation, chemistry, and bioactivity studies

Paper ID Volume ID Publish Year Pages File Format Full-Text
35093 45074 2009 8 PDF Available
Title
Exploring the potential of biopharmaceutical production by Rigidoporus ulmarius: Cultivation, chemistry, and bioactivity studies
Abstract

Rigidoporus ulmarius is used as a medicinal fungus in Asia. Three isolates (denoted #61, #62, and #63) of R. ulmarius were collected, and their biological activities were evaluated. Extracted polysaccharides from isolate #63 showed greater inhibition activity compared to isolates #61 and #62 in an in vitro endothelial cell tube formation assay, a standard evaluation of angiogenesis. The polysaccharides and ethanolic extract of isolate #63 dose-dependently suppressed the production of the interferon (IFN)-γ-induced inflammation marker, IP-10. Chemical analyses of the polysaccharides revealed that isolate #63 contained the highest value of fucose at a concentration of 59.1 ± 1.2 μmol/g polysaccharide. These results suggest that fucose-containing polysaccharides may play a role in the inhibitory effect. Isolate #63 showed the highest values of ADP among the three isolates in the ethanolic extract. These results suggest that different isolates from R. ulmarius exhibit different abilities to regulate antiangiogenic and anti-inflammatory processes.

Keywords
Rigidoporus ulmarius; Polysaccharides; Nucleoside; Antiangiogenesis; Anti-inflammation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 44, Issue 11, November 2009, Pages 1237–1244
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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