fulltext.study @t Gmail

Effect of acyl donor chain length on isoquercitrin acylation and biological activities of corresponding esters

Paper ID Volume ID Publish Year Pages File Format Full-Text
35117 45076 2010 8 PDF Available
Title
Effect of acyl donor chain length on isoquercitrin acylation and biological activities of corresponding esters
Abstract

The enzymatic acylation of isoquercitrin with fatty acid esters of various carbon chain lengths was carried out in 2-methyl-2-butanol using Novozym 435®. The conversion yield and the initial rate decreased from 66% to 38% and from 17.7 to 10.1 μmol/h respectively, as the carbon chain of the acyl donor increased from C4 to C18. Isoquercitrin acylated derivatives showed higher xanthine oxidase inhibition activities than isoquercitrin. This property increased with the lipophilicity of the derivative esters. The scavenging activity of isoquercitrin esters against ABTS and DPPH radicals decreased with the acyl chain length. Conversely, for esters from C6 to C18, a linear growing relationship can be established between the chain length and the superoxide radical scavenging activity. Furthermore, an improved antiproliferative effect on Caco2 cancer cells was induced by addition of isoquercitrin esters comparing with isoquercitrin.

Keywords
Isoquercitrin; Enzymatic acylation; Candida antarctica lipase B; Flavonoid esters; Antioxidant activity; Antiproliferative activity
First Page Preview
Effect of acyl donor chain length on isoquercitrin acylation and biological activities of corresponding esters
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 45, Issue 3, March 2010, Pages 382–389
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us