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Microbial succinic acid production: Natural versus metabolic engineered producers

Paper ID Volume ID Publish Year Pages File Format Full-Text
35184 45080 2010 12 PDF Available
Title
Microbial succinic acid production: Natural versus metabolic engineered producers
Abstract

The increased consciousness for environmental issues and the depletion of mineral oil reserves led to the search for alternative energy sources but also for alternative biochemical processes. One of these chemicals that is identified to have great economical potential in a biobased economy is succinic acid. This chemical is a precursor for various high value-added derivatives which have application in the detergent/surfactant market, the ion chelator market, the food market and the pharmaceutical market.This review investigates the goals and preconditions to have an economical viable biosuccinic acid process. The different production hosts for biosuccinic acid are examined and the metabolic engineering strategies and possibilities are discussed. Finally, the state of the art of biosuccinic acid production processes is critically evaluated in function of the production host, media, fermentation strategy, titers and yields.

Keywords
Succinic acid; Metabolic engineering
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 45, Issue 7, July 2010, Pages 1103–1114
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us