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Optimization of culture medium for cordycepin production using Cordyceps militaris mutant obtained by ion beam irradiation

Paper ID Volume ID Publish Year Pages File Format Full-Text
35220 45081 2010 4 PDF Available
Title
Optimization of culture medium for cordycepin production using Cordyceps militaris mutant obtained by ion beam irradiation
Abstract

The effect of medium components on cordycepin production by Cordyceps militaris mutant obtained by ion beam irradiation was investigated. According to the response surface analysis using a central composite design for the prospective mutant G81-3, the predicted optimal concentrations of glucose as the carbon source and the yeast extract as the nitrogen source were 86.2 g/l and 93.8 g/l, respectively, and 6.84 g/l cordycepin was obtained. To date, this is the highest value for cordycepin production. The optimal concentrations of glucose and yeast extract for cordycepin production of the mutant was much higher than that of control (wild strain) and the cordycepin production was 2.79 times higher. Therefore, this new mutant will be a promising strain for future higher cordycepin production at industrial levels.

Keywords
Cordyceps militaris mutant; Cordycepin; Surface liquid culture; Medium optimization; Response surface analysis; Central composite design
First Page Preview
Optimization of culture medium for cordycepin production using Cordyceps militaris mutant obtained by ion beam irradiation
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 45, Issue 1, January 2010, Pages 129–132
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering