fulltext.study @t Gmail

Enantioselective acylation of (RS)-phenylethylamine catalysed by lipases

Paper ID Volume ID Publish Year Pages File Format Full-Text
35301 45085 2009 6 PDF Available
Title
Enantioselective acylation of (RS)-phenylethylamine catalysed by lipases
Abstract

The enzymatic acylation of (RS)-phenylethylamine with different acyl donors catalysed by lipases, was studied in organic solvents with different hydrophobicities and in mixtures with ionic liquids ((ILs); [BMIm][BF4], [BMIm][SCN], [BMIm][Cl] and [BMIm][PF6]). Using lipases from Candida antarctica B (CAL-B) and from Aspergillus niger higher conversion degrees and E-values were obtained with ethyl acetate as the acyl donor. When CAL-B was used as the biocatalyst, in a two-phase system formed by [BMIm][X]/dichloromethane or [BMIm][X]/chloroform, the selectivity was better than that obtained in pure organic solvents. The selectivity was found to be related to individual anions in ILs. In this reaction, the ion effectiveness in enhancing the enzyme selectivity followed the series: Cl− > SCN− > BF4− > PF6− in mixtures with dichloromethane, and PF6− > BF4− > SCN− > Cl− in mixtures with chloroform.

Keywords
Acylation; Amine; Lipases; Organic solvents; Acyl donors
First Page Preview
Enantioselective acylation of (RS)-phenylethylamine catalysed by lipases
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 44, Issue 12, December 2009, Pages 1352–1357
Authors
, , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us