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Production and statistical optimization of a novel olivanic acid by Streptomyces olivaceus MTCC 6820

Paper ID Volume ID Publish Year Pages File Format Full-Text
35326 45086 2008 5 PDF Available
Title
Production and statistical optimization of a novel olivanic acid by Streptomyces olivaceus MTCC 6820
Abstract

A microbial strain, isolated from soil samples, characterized as Streptomyces olivaceus MTCC 6820 showed broad-spectrum antibacterial activity. The compound produced was chemically characterized as a new form of olivanic acid. Olivanic acid production was optimized statistically by Plackett-Burman design (PBD) and response surface methodology (RSM). Effects of soybean meal, glycerol, CaCO3 and dl-alanine were investigated with the help of PBD. The individual and interaction effects of the studied variables were evaluated by RSM using central composite design (CCD). By applying statistical design, antibiotic production was enhanced nearly 8 times (415 mg/l) as compared with the normal production medium (50 mg/l).

Keywords
Olivanic acid; Streptomyces olivaceus; Optimization; Plackett-Burman design; Response surface methodology; Response surface/contour plots
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Production and statistical optimization of a novel olivanic acid by Streptomyces olivaceus MTCC 6820
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 43, Issue 11, November 2008, Pages 1313–1317
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us