fulltext.study @t Gmail

Inactivation of a TSE agent by a novel biorefinement system

Paper ID Volume ID Publish Year Pages File Format Full-Text
35347 45087 2009 3 PDF Available
Title
Inactivation of a TSE agent by a novel biorefinement system
Abstract

The infectious agents causing transmissible spongiform encephalopathies (TSEs), sometimes called prions, are notoriously difficult to completely inactivate or destroy. Here we tested a thermal hydrolysis system which combines saturated steam heating to 180 °C (10 bar), with stirring. The 301V-TSE strain, which has been derived by passage of BSE in mice, was used since it is the most thermostable TSE strain tested so far. All detectable TSE infectivity was destroyed, with a clearance factor of greater than 105 ID50. The use of this technology for the decontamination of TSE infected tissue waste and the potential uses of the end-products are discussed.

Keywords
TSE; BSE; Prion; Heat inactivation; Heat hydrolysis
First Page Preview
Inactivation of a TSE agent by a novel biorefinement system
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 44, Issue 9, September 2009, Pages 1060–1062
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us