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The influence of arrangement sequence on the glucose-responsive controlled release profiles of insulin-incorporated LbL films

Paper ID Volume ID Publish Year Pages File Format Full-Text
354 38 2012 9 PDF Available
Title
The influence of arrangement sequence on the glucose-responsive controlled release profiles of insulin-incorporated LbL films
Abstract

Insulin, glucose oxidase and positively charged star polymers were incorporated into multilayer films by the layer-by-layer (LbL) assembly method. It is interesting to find that the arrangement sequence of the three components could significantly affect the glucose-responsive controlled release behaviors. The insulin release in vitro could be tuned to linear release and obtain desired “on–off” sensitivity in response to stepwise glucose challenge, just by rearranging the assembly sequence of LbL building blocks. Further, the controlled release of insulin in vivo, as well as the hypoglycemic effect, could be obviously prolonged from 17 days to 36 days by this simple strategy without changing the dosage of all the LbL components. In addition to provide a potential glucose-responsive delivery system for insulin, the strategy described in this paper could be valuable for various drug-incorporated LbL systems with three or more components.

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Keywords
Drug delivery; LbL films; Star polymer; Controlled release; Insulin
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The influence of arrangement sequence on the glucose-responsive controlled release profiles of insulin-incorporated LbL films
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 8, Issue 12, December 2012, Pages 4380–4388
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us