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Scale-up study on the fed-batch fermentation of Ganoderma lucidum for the hyperproduction of ganoderic acid and Ganoderma polysaccharides

Paper ID Volume ID Publish Year Pages File Format Full-Text
35406 45088 2011 5 PDF Available
Title
Scale-up study on the fed-batch fermentation of Ganoderma lucidum for the hyperproduction of ganoderic acid and Ganoderma polysaccharides
Abstract

Besides the identified key factors of pH-shift from 3.0 to 4.5 on day 4 and dissolved oxygen tension (DOT) shift from 25 to 10% on day 6, lower shear stress was also demonstrated to be a key factor in scaling-up the fed-batch fermentation of the medicinal mushroom Ganoderma lucidum from a shake flask to a stirred-tank bioreactor. The maximal biomass (22.62 g/L), intercellular polysaccharide production (4.74 g/L), and ganoderic acid production (798.0 mg/L) were attained at a low impeller tip speed of 1.234 m/s. Based on the identified key factors of pH-shift, DOT-shift and lower shear stress, the fed-batch fermentation of G. lucidum was successfully step-wise scaled-up from 7.5- to 200-L stirred-tank bioreactor. Through the qualitative and quantitative side-by-side comparison of G. lucidum growth and metabolites accumulation, it was concluded that the comparability of the fed-batch fermentation process were well controlled and the products were maintained during the process scale-up.

Keywords
Scale-up; Fed-batch fermentation; Ganoderma lucidum; Ganoderic acid; Ganoderma polysaccharides
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Scale-up study on the fed-batch fermentation of Ganoderma lucidum for the hyperproduction of ganoderic acid and Ganoderma polysaccharides
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 46, Issue 1, January 2011, Pages 404–408
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us