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A convenient preparation of dityrosine via Mn(III)-mediated oxidation of tyrosine

Paper ID Volume ID Publish Year Pages File Format Full-Text
35427 45089 2008 5 PDF Available
Title
A convenient preparation of dityrosine via Mn(III)-mediated oxidation of tyrosine
Abstract

A simple method to rapidly and conveniently prepare dityrosine from l-tyrosine was developed using Mn(III) as an oxidizing agent. The best yield of the reaction was obtained from the 1 min equimolar reaction of l-tyrosine with Mn(III) acetate in 0.2 M sodium phosphate solution (pH 2.1) at 25 °C. Phosphate was removed by precipitation in ammonia water. The remaining tyrosine was mostly eliminated by precipitation in cold acidic water. Dityrosine was then further purified by HPLC, and its chemical structure was identified by NMR spectroscopy. Even though the yield was only 15.8%, this one-step Mn(III)-mediated oxidation of tyrosine allows dityrosine to be prepared without the need for complicated multi-step organic reactions.

Keywords
Mn(III)-mediated oxidation; Tyrosine; Dityrosine; Phosphate; Purification; Product identification
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A convenient preparation of dityrosine via Mn(III)-mediated oxidation of tyrosine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 43, Issue 9, September 2008, Pages 999–1003
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us