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Purification of lactic acid from microfiltrate fermentation broth by cross-flow nanofiltration

Paper ID Volume ID Publish Year Pages File Format Full-Text
3547 174 2012 8 PDF Available
Title
Purification of lactic acid from microfiltrate fermentation broth by cross-flow nanofiltration
Abstract

Experimental investigations were carried out on cross-flow nanofiltration of microfiltrate fermentation broth of lactic acid during membrane-integrated fermentative production of monomer grade lactic acid. Three types of composite polyamide nanofiltration membranes (NF2, NF3 and NF20) manufactured by Sepro Co. (USA) were used in nanofiltration. Lactic acid fermentation broth produced by fermentation of sugar cane juice by Lactobacillus plantarum in a membrane-integrated hybrid reactor system was filtered by NF membranes after preliminary filtration through microfiltration membranes for cell separation and recycle. Effects of cross flow rate, transmembrane pressure and pH on flux and rejection of both acid and unconverted sugars for recycle were analyzed. NF3 membrane was successful in retaining 94% unconverted sugars while allowing 32% lactic acid to permeate at a flux of 113 L m−2 h−1 at pH 5.5, temperature 37 °C, transmembrane pressure of 13 bar and cross-flow velocity 2.48 m s−1. The study shows that integration of a properly selected nanofiltration membrane with a cell-recycle fermentation unit and lactate conversion unit can yield l (+) lactic acid with an optical purity of 85.6% through an economically attractive route by recovering and recycling of unconverted sugars. The nanofiltration combine with bipolar electrodialysis in downstream purification can replace the multiple purification steps by two steps while yielding a monomer grade lactic acid from a mixture of unconverted sugars and lactic acid.

► Cross flow nanofiltration. ► Study of nanofiltration membrane with a cell-recycle fermentation unit for high purity l (+) lactic acid. ► Lactic acid fermentation broth produced by fermentation of sugar cane juice with the help of Lactobacillus plantarum. ► Recovery and recycle of unconverted sugars making the process economically attractive.

Keywords
Cross-flow; Membrane separation; Fermentation broth; Lactic acid; Nanofiltration; Sugar recovery
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Purification of lactic acid from microfiltrate fermentation broth by cross-flow nanofiltration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 69, 15 December 2012, Pages 130–137
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us