fulltext.study @t Gmail

Scale-up of micro-aerobic 1,3-propanediol production with Klebsiella pneumonia CGMCC 1.6366

Paper ID Volume ID Publish Year Pages File Format Full-Text
35499 45092 2009 5 PDF Available
Title
Scale-up of micro-aerobic 1,3-propanediol production with Klebsiella pneumonia CGMCC 1.6366
Abstract

The conversion of glycerol to 1,3-propanediol (1,3-PD) using Klebsiella pneumoniae CGMCC 1.6366 under aerobic condition was scaled up from scale 5 to 50,000 l in series. Several parameters including power input P/Vl, agitation rate n, impeller tip speed nD, superficial gas velocity us, and Res were investigated as the criteria for scaling up. Impeller tip speed was chosen as the main criterion. It was also noticed less aeration was favored in that less electron will be shunted to electron transfer chain. The fermentation in 500 l bioreactor produced 66.8 g 1,3-PD with the yield of 0.55 mol mol−1 at agitation rate and aeration of 130 rpm and 0.14 vvm air flow. Using these empirically obtained control concepts we successfully scaled up in 500–50,000 l pilot-scale reactors. The final 1,3-PD concentrations in 50,000 l bioreactor amounted to 63.3 g l−1 with the yield of 0.5 mol mol−1.

Keywords
1,3-Propanediol; Fermentation; Klebsiella pneumoniae; Scale-up; Impeller tip speed; Glycerol
First Page Preview
Scale-up of micro-aerobic 1,3-propanediol production with Klebsiella pneumonia CGMCC 1.6366
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 44, Issue 8, August 2009, Pages 944–948
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us