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Anti-inflammatory activity of caffeic acid phenethyl ester (CAPE) extracted from Rhodiola sacra against lipopolysaccharide-induced inflammatory responses in mice

Paper ID Volume ID Publish Year Pages File Format Full-Text
35580 45096 2008 5 PDF Available
Title
Anti-inflammatory activity of caffeic acid phenethyl ester (CAPE) extracted from Rhodiola sacra against lipopolysaccharide-induced inflammatory responses in mice
Abstract

A potent anti-inflammatory activity was detected from methanol extracts prepared from roots of Rhodiola sacra. In the preliminary test, methanol extracts from the roots of R. sacra could potently attenuate histological change in the lung tissue after lipopolysaccharide (LPS)-treated inflammatory stimulation. The active compound has been identified as 3-(3,4-dihydroxy-phenyl)-acrylic acid phenethyl ester (caffeic acid phenethyl ester, CAPE). In vivo study on protective effect of R. sacra CAPE against inflammatory response by endotoxin shock in the LPS-induced inflammatory mice showed significantly attenuated the intravenous LPS-induced increase in plasma TNF-α and IL-1β concentration. R. sacra CAPE significantly inhibited LPS-induced nuclear transcription factor-κB (NF-κB) activation. It also down-regulates enhanced matrix metalloproteinase-9 (MMP-9) activity triggered by LPS in mouse lung. In the present study, the results indicate that the intake of R. sacra CAPE could provide health benefits, reducing the magnitude of the inflammatory process triggered by endotoxin shock and the production of inflammatory mediators.

Keywords
Anti-inflammatory activity; Rhodiola sacra; Caffeic acid phenethyl ester (CAPE); Endotoxin shock; Lipopolysaccharide (LPS); Matrix metalloproteinase-9 (MMP-9)
First Page Preview
Anti-inflammatory activity of caffeic acid phenethyl ester (CAPE) extracted from Rhodiola sacra against lipopolysaccharide-induced inflammatory responses in mice
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 43, Issue 7, July 2008, Pages 783–787
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering