fulltext.study @t Gmail

Power input correlation to characterize the hydrodynamics of cylindrical orbitally shaken bioreactors

Paper ID Volume ID Publish Year Pages File Format Full-Text
3569 175 2012 7 PDF Available
Title
Power input correlation to characterize the hydrodynamics of cylindrical orbitally shaken bioreactors
Abstract

Disposable cylindrical shaken bioreactors using plastic bags or vessels represent a promising alternative to stainless steel bioreactors, because they are flexible, cost-effective and can be pre-sterilized. Unlike conventional well-established steel bioreactors, however, such disposable bioreactor systems have not yet been precisely characterized. Thus, the aim of this current work is to introduce a new power input correlation as a potential means to characterize the hydrodynamics of these new systems. A set of relevant power input variables was defined and transformed into dimensionless numbers by using the Buckingham's π-Theorem. These numbers were then experimentally varied to quantify the relationship among the numbers. A simple correlation was generated for the power input with seven variables. The application of this new correlation was validated using 200 L and 2000 L orbitally shaken bioreactors. In conclusion, the proposed correlation is a useful tool to predict the power input and hydrodynamics during cell cultivation in cylindrical shaken bioreactors of all scales.

► Introduction of a new power input correlation for disposable orbitally shaken bioreactors. ► Application validated using 200 L and 2000 L orbitally shaken bioreactors. ► Prediction of power input and hydrodynamics in cylindrical shaken bioreactors of all scales.

Keywords
Power input; Disposable bioreactors; Single use; orbitally shaken; Hydrodynamics
First Page Preview
Power input correlation to characterize the hydrodynamics of cylindrical orbitally shaken bioreactors
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 65, 15 June 2012, Pages 63–69
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us