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Review on production and medical applications of ɛ-polylysine

Paper ID Volume ID Publish Year Pages File Format Full-Text
3570 175 2012 12 PDF Available
Title
Review on production and medical applications of ɛ-polylysine
Abstract

ɛ-Polylysine (ɛ-PL) is a homopolyamide linked by the peptide bond between the carboxylic and epsilon amino group of adjacent lysine molecules. It is naturally occurring biodegradable and nontoxic towards human. This review article gives an insight about the various ɛ-PL producing strains, their screening procedures, mechanism of synthesis, characterization, and its application in the medical field. The poly cationic nature of ɛ-PL at physiological pH makes it as one of the potential candidates in the field of drug delivery. Most of the biomedical applications till date use synthetic α-PLL as a raw material. However, it is believed that naturally occurring ɛ-PL would be an ideal substitute.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► ɛ-Polylysine is naturally occurring biodegradable and nontoxic towards human. ► A comprehensive report on biosynthetic mechanism and molecular genetics of ɛ-PL production were discussed. ► Strain isolation, microbial production and purification of ɛ-PL were also discussed. ► ɛ-PL have various biomedical application like dietary agent, drug carriers, anticancer agent enhancer, biochip coatings.

Keywords
Pls, polylysine synthetase; NaSCN, sodium thiocynate; FTIR, Fourier transform infrared spectroscopy; NMR, nuclear magnetic resonance spectroscopy; MION, monocrystalline iron oxide nanoparticle; NPs, nanoparticles; IgM, immunoglobulin Mɛ-Polylysine; Homopo
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Review on production and medical applications of ɛ-polylysine
Publisher
Database: Elsevier - ScienceDirect
Journal: Biochemical Engineering Journal - Volume 65, 15 June 2012, Pages 70–81
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering