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Enhancement of gentamicin production by mutagenesis and non-nutritional stress conditions in Micromonospora echinospora

Paper ID Volume ID Publish Year Pages File Format Full-Text
35706 45102 2007 5 PDF Available
Title
Enhancement of gentamicin production by mutagenesis and non-nutritional stress conditions in Micromonospora echinospora
Abstract

Gentamicin producing strain of Micromonospora echinospora was treated with chemical mutagens like EtBr and MNNG and physical mutagens such as UV was carried out to obtain a mutant with enhanced production of gentamicin. After inducing mutations screening for penicillin and kanamicin resistant mutants was done. M. echinospora EtBr-22 strain was obtained by mutations and its gentamicin production in shake flask reaches 1354 mg l−1 which is 1.53-fold higher than that of the parent strain. Application of different stress conditions like heat shock, feeding high ethanol and high NaCl concentrations during fermentation has found to be effective for the increased production of gentamicin. Production of gentamicin was increased to 1.26-fold in medium supplemented with 0.6% NaCl to 48-h-old culture.

Keywords
Micromonospora; Gentamicin; Mutations; Stress conditions; Heat shock; Salt stress
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Enhancement of gentamicin production by mutagenesis and non-nutritional stress conditions in Micromonospora echinospora
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 42, Issue 9, September 2007, Pages 1352–1356
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us