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Enantioselective reduction of aryl ketones using immobilized cells of Candida viswanathii

Paper ID Volume ID Publish Year Pages File Format Full-Text
35802 45107 2007 7 PDF Available
Title
Enantioselective reduction of aryl ketones using immobilized cells of Candida viswanathii
Abstract

Enantioselective reduction of 1-acetonapthone to S(−)-1-(1-naphthyl) ethanol, a key intermediate for the synthesis of HMG Co-A reductase inhibitor, was successfully carried out using immobilized cells of a newly isolated carbonyl reductase producing yeast strain Candida viswanathii MTCC 5158. Calcium alginate (1.5%, w/v) gave the best immobilization efficiency. Among different organic solvents and ionic liquids tried as reaction media, isopropanol gave the best enantioselectivity with moderate conversion. The immobilized cells (100 mg/ml in 50 mM Tris buffer pH 9) showed best results at a substrate concentration of 0.2 mg/ml at 30 °C. After twelve cycles of reaction, no significant decrease in bioreduction efficiency of the immobilized cells was observed as compared to the free cells.

Keywords
Immobilized cells; Candida viswanathii; Enantioselective reduction; Organic solvents
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Enantioselective reduction of aryl ketones using immobilized cells of Candida viswanathii
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 42, Issue 10, October 2007, Pages 1412–1418
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
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