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Effect of two ergosterol biosynthesis inhibitors on lycopene production by Blakeslea trispora

Paper ID Volume ID Publish Year Pages File Format Full-Text
35809 45107 2007 5 PDF Available
Title
Effect of two ergosterol biosynthesis inhibitors on lycopene production by Blakeslea trispora
Abstract

Limiting ergosterol accumulation through metabolic control increased lycopene production by Blakeslea trispora. Lycopene and ergosterol are both biosynthesized from a common precursor, farnesyl diphosphate (FPP). The effects of two ergosterol biosynthesis inhibitors, terbinafine hydrochloride (TH) and ketoconazole, on the production of lycopene by B. trispora were investigated. TH at 0.7 mg/l and ketoconazole at 30 mg/l added to the medium at 48 h of fermentation caused an increase in lycopene content of 23% or 277%, respectively. The timing of addition for both inhibitors at 48 h resulted in the most optimal lycopene productivity, however, compared with TH, ketoconazole was superior in enhancing lycopene production by inhibiting ergosterol biosynthesis.

Keywords
Lycopene; Ergosterol; Blakeslea trispora; Inhibitor; Terbinafine hydrochloride (TH); Ketoconazole
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Effect of two ergosterol biosynthesis inhibitors on lycopene production by Blakeslea trispora
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 42, Issue 10, October 2007, Pages 1460–1464
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
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Price after discount Only $4.95
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