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Oxygen enrichment effects on protein oxidation, proteolytic activity and the energy status of submerged batch cultures of Aspergillus niger B1-D

Paper ID Volume ID Publish Year Pages File Format Full-Text
35829 45109 2008 6 PDF Available
Title
Oxygen enrichment effects on protein oxidation, proteolytic activity and the energy status of submerged batch cultures of Aspergillus niger B1-D
Abstract

Oxygen enrichment (sparging bioreactors with oxygen-enriched air) ameliorates oxygen limitation in batch cultures of Aspergillus niger B1-D, and although nutrient utilization rates for both the carbon source and the nitrogen source are higher in oxygen-enriched cultures, excess oxygen does not enhance specific growth rate, instead the “extra” nutrient consumption is associated with defensive measures. Commencement of oxygen enrichment in early exponential phase leads to a transient rise in proteins showing oxidative damage (carbonylation), and to induction of enhanced proteolytic activity, which points to the antioxidant defense being temporarily overwhelmed, and that A. niger adapts to this oxidative environment by enhancing intracellular proteolytic activity to degrade damaged proteins which might otherwise accumulate under these conditions. Also the energy status of A. niger, reflected by intracellular ATP content, is found to be altered upon the commencement of oxygen enrichment and then reaches much lower levels than in the control. The reasons underlying this are discussed in the context of what is known regarding alternative respiration in industrial fungi.

Keywords
Oxygen enrichment; Aspergillus niger; Fermentation; Protein carbonyl; Proteolytic activity; ATP
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Oxygen enrichment effects on protein oxidation, proteolytic activity and the energy status of submerged batch cultures of Aspergillus niger B1-D
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Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 43, Issue 3, March 2008, Pages 238–243
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us