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Retamycin production by immobilized cells of Streptomyces olindensis ICB20 in repeated-batch cultures

Paper ID Volume ID Publish Year Pages File Format Full-Text
35850 45110 2008 6 PDF Available
Title
Retamycin production by immobilized cells of Streptomyces olindensis ICB20 in repeated-batch cultures
Abstract

Repeated-batch cultures of Ca-alginate immobilized cells of Streptomyces olindensis ICB20 for retamycin production were carried out in two different bioreactors: a basket-type stirred tank reactor (BSTR) and a bubble column reactor (BCR). Higher average values of retamycin content (R) and productivity (PR) were achieved in the BSTR cultures (about 1.7 AU and 0.031 AU h−1, respectively) compared to those obtained in the BCR cultures (about 0.6 AU and 0.012 AU h−1, respectively). The BCR, on the other hand, presented significantly better operation stability than the BSTR, which makes the former much more promising regarding future industrial applications.

Keywords
Streptomyces olindensis; Immobilized cells; Retamycin; Repeated-batch; Basket-type tank reactor; Bubble column reactor
First Page Preview
Retamycin production by immobilized cells of Streptomyces olindensis ICB20 in repeated-batch cultures
Publisher
Database: Elsevier - ScienceDirect
Journal: Process Biochemistry - Volume 43, Issue 6, June 2008, Pages 661–666
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering